Clinical significance of MS


In the clinical laboratories for the diagnosis of disease, disease screening and metabolic disorders, monitoring of the drug therapy, identifying the drug poisoning and toxicity and regulation of the advanced biomarkers the mass spectrometry technology have been used. By the application of the mass spectrometry technique the therapeutic regulation of immunosuppressant drugs is well established. For the evaluation of the steroidal hormones for the endocrine disorders and vitamin D, the liquid chromatography-mass spectrometry is the best technique in the clinical laboratories. The tandem mass spectrometry is used for the measurement of the thyroid hormones which have overcome the issue with immunoassays. For the toxic drug quantitation and toxicology screening the triple quadrupole mass spectrometry is preferred. In clinical microbiology laboratories for the rapid identification of the microorganism automated MALDI-TOF MS technology is applied.
For the screening of toxicology and quantification of toxic drug the method that is preferred is triple quadrupole MS/MS.  Electrospray, tandem mass spectrometry (MS/MS) is used for laboratory testing technology for new-born and prenatal screening for many errors of metabolism.  Electrospray tandem mass spectrometry new born screening technology is continuously expanding due to its advantage in screening infants for many uncommon inborn diseases.  The other bright significance of MS is the estimation of endogenous metabolites as new disease biomarkers that is acceptable to clinical application and discovery of metabolite characterization
MS technique have a wide variety of application in the clinical field and still there are provocation that include online extraction, sample preparation, throughput, laboratory information system interfacing, automation, inter-instruments standardization and harmonization and FDA regulation.

Join us for the upcoming 10th International Conference on Mass Spectrometry and Chromatography going to be held during October 08-09, 2018, in beautifully crafted city Dubai, UAE which features various advancements and future trends in mass spectrometric analysis and chromatographic techniques.



Comments

Post a Comment

Popular posts from this blog

Image
Gas chromatography and mass spectrometry- welcome news for chocolate lovers Apart from other research, gas chromatography and mass spectrometry, the heartbeat of analytical tools again proved to be bonus for the chocolate lovers. Serotonin called as mood lifter found in chocolate, which is manufactured by cocoa beans. Chocolate change the mood and is loved by every category of population. Jackfruit found in most of the tropical region which are very low cost and are now replacement for cocoa beans, which is the main constituent in chocolate. The demand of chocolate in the world is elevating day by day and beating the production of cocoa beans. The sweet smelling jackfruit are boiled, roasted and steamed prior to eating, which is the cheap source of protein, fibre, and minerals, and these are mostly thrown as waste. The analysis predicted that the demand for these beans will cross 4 million tonnes by 2020.Researchers were finding a better way to put the waste jackfruits
Read more
Image
SOLICITATION OF IONIZATION TECHNIQUE IN MASS SPECTROMETRY There are many ionization techniques combined with Mass spectrometry.  Electron impact (EI) and  Fast Atom Bombardment (FAB) are the classical ionization technique used mainly by the chemist. Now, these  techniques for ionization  are not generally used in modern mass spectrometry except EI for environmental work using GC-MS.   Atmospheric Pressure Chemical Ionization (APCI), electrospray ionization (ESI), Matrix Assisted Laser Desorption Ionization (MALDI) are Modern Ionization techniques in mass spectrometry. APCI forms a protonated molecule and is completely compatible with  Liquid Chromatography  (LC) and so it is more preferred over EI methods. Electrospray Ionization Method Combined with  Matrix-assisted laser desorption ionization  (MALDI) has eliminated the application of FAB because it produces the protonated molecules, which made FAB very popular but is much more sensitive.   Electrospray ionizat
Read more
Image
Proteomic Experiment: Mass Spectrometry Cellular factories localize and push proteins into compartments where they perform their variety of the functions and subcellular protein provide high-end indication for its activities. Researchers can envisage protein dispersal in the cell by using Super-resolution microscopy by applying antibodies or by tagging proteins with florescent probes. Such kind of method is not innovative and researchers have to pin down their choice of proteins to a known set. Unbiased Mass Spectrometry based proteomic method present expansive way, and the credit goes to the specificity, accuracy and scale they provide. Lately researchers are using the approach to learn protein activity at the sub cellular level. The new dubbed spatial proteomic methodology, offer researchers to build a comprehensive cellular maps and show the hidden life of proteins- who they interact with, where they live & they move around- in healthy as well as in diseased cells. We
Read more