Divine Sanction for Analytical World: Mass Spectrometry and Chromatography

Mass spectrometry is a revolution to the analytical world which have boosted up the analytical market due to its wonderful characteristic of quantitative and qualitative determination. Mass spectrometry has made the analysis very simpler and broader by its superior feature which is irreplaceable. Mass spectrometry plays its role in every stage of analysis and is the major tool in every field from medicine to agriculture. This technique is getting modified in every corner of this technical world.
Researchers are further modifying these techniques to be applied for different fields. Without this technique the analytical world is incomplete as this is the only technique which solve the queries of the experiments by giving appropriate result. In tumorigenesis, role of histidine phosphorylation is the most recent experiment. Histidine phosphorylation is the hidden phosphoproteome. When 12 tumours are proteomically analysed by mTOR-driven hepatocellular carcinoma mouse, it was observed from the model that NME1 & NME2 mammalian kinase were coordinated. At variance specifically in the tumours the expression of the putative histidine phosphatase was de-regulated. It was demonstrated that LHPP is absolutely protein histidine phosphatase. In the liver tumours the global histidine phosphorylation was remarkably upregulated in the observation. Reduction of tumour burden was observed in the hepatic expression of LHPP in the hepatocellular carcinoma mouse and block the deficiency of the liver function. It was concluded that low expression of LHPP associated with the elevated tumour acerbity and diminished total survival in the patients with hepatocellular carcinoma. Therefore, LHPP is a tumour suppressor and protein histidine phosphatase that decontrol histidine phosphorylation is oncogenic.
This observation was successful only by the aid of mass spectrometry. Researchers are very thankful for this analytical tool  that had bloomed up the research and their modification. Many more interesting topics are going to be discussed by the world’s eminent speakers at the most awaited 10th International Conference on Mass Spectrometry and Chromatography during October 08-09, 2018 at the most beautifully crafted city Dubai, U.A.E. This conference is going to bring together a unique and International mix of experts and boost you up with knowledge, new ideas and research work. This conference hosts prompt keynote presentations, Oral talks, Poster presentations and Exhibitions.  This conference would promise to be the best platform for all the researchers, knowledge seekers and people to exchange their experience, knowledge and research innovations.


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