A Powerful analytical tool- Mass Spectrometry

Mass Spectroscopy is one of the most powerful tools in analytical chemistry and its role is most significant in drug discovery proving it as the cornerstone of systems biology. Innovation is driving a drastic change in high-resolution technologies like matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF). Data independent analysis and hyper reaction monitoring have been emerged in mass spectrometry methods. Experiments can be conducted with full high-resolution product ion spectra, potentially leading to higher sequence coverage or analytical selectivity. Fundamentally this method does not change the shape of proteomics, hence it is a very useful tool that must expedite discovery in biology. This technique has emerged as the premier method for the analysis of biomolecules. Improvement in instruments has been done in combination with the introduction of many new approaches for the preparation and separation of the target molecules.

The new mass spectrometer, focus on the advancement of the biotechnology with its accessibility as financially as well as technically in the laboratories with broad specialization in its application.

The new mass spectrometry technology considers hardware design for the movement of fragile molecules in the gaseous ionized form where they can be analysed. These consist of electrospray ionization, matrix-assisted laser desorption/ionization (MALDI) and surface enhanced laser desorption/ionization (SELDI). Mass spectroscopy is the leading technology for the identification of the biomolecules, and it will make a breakthrough advancement in the diagnosis and knowing of a host recalcitrant disease.