SOLICITATION OF IONIZATION TECHNIQUE IN MASS SPECTROMETRY There are many ionization techniques combined with Mass spectrometry. Electron impact (EI) and Fast Atom Bombardment (FAB) are the classical ionization technique used mainly by the chemist. Now, these techniques for ionization are not generally used in modern mass spectrometry except EI for environmental work using GC-MS. Atmospheric Pressure Chemical Ionization (APCI), electrospray ionization (ESI), Matrix Assisted Laser Desorption Ionization (MALDI) are Modern Ionization techniques in mass spectrometry. APCI forms a protonated molecule and is completely compatible with Liquid Chromatography (LC) and so it is more preferred over EI methods. Electrospray Ionization Method Combined with Matrix-assisted laser desorption ionization (MALDI) has eliminated the application of FAB because it produces the protonated molecules, which made FAB v...
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